ArthroNovus was founded in 2025 to pursue development of structural autologous solutions to osteoarthritis. We believe total joint replacement is an end-stage solution which can be prevented. In partnership with experts at University Hospitals and Case Western Reserve University, we are developing a new therapeutic treatment for focal cartilage defects.

We also provide services to those seeking expertise in cell biology, tissue engineering and mechanical conditioning of tissues. Contact us to discuss your project.

Our Leadership:

Paul Gallese, PT, MBA Co-Founder, President & CEO	Paul is a pathokinesiologist with a proven track record in healthcare administration and startups. He brings intimate knowledge of healthcare finance, purchasing approvals and regulatory compliance. Paul was a business advisor to the CWRU OMEGA program.
Daniel Savage, PE Co-Founder & Chief Technology Officer	Dan is a 30-year veteran of orthopaedic research and development in spine, fixation and joint arthroplasty. He was previously the VP of R&D and Operations for ActivOrtho, Inc., and served as the Executive Director of the CWRU OMEGA program.
James Voos, MD Co-Founder & Chief Medical Officer	Dr Voos is an Industry key opinion leader in Sports Medicine and Orthopaedics. He is currently the Chair of the University Hospitals Department of Orthopedic Surgery, the Cleveland Browns Head Team Physician and President of NFL Physicians Association. Dr. Voos was a clinical advisor to the CWRU OMEGA program.
Jacob Calcei, MD Co-Founder & Principal Designing Surgeon	Dr. Calcei is a fellowship-trained orthopedic sports medicine expert. He is a Cleveland Browns Team Physician and has appointments in the University Hospitals Department of Orthopedic Surgery, and as an Associate Professor of Orthopaedics, CWRU School of Medicine. Dr. Calcei was a clinical advisor to the CWRU OMEGA program.